Diagnostic and Surveillance Testing

Biomarkers and Genomic Testing
Introduction
What are biomarkers?
Current CRC biomarkers
MSS and MSI-H: something every CRC patient should know
What common genomic alterations do biomarker tests look for?
CRC biomarkers: quick overview
Predictive CRC biomarkers: Dr. Kopetz and Dr. Kim
Circulating tumor DNA (cTDNA): Dr. Cohen
Biomarker testing rates: current state for CRC patients in the U.S.
cTDNA tests for Minimal Residual Disease Detection: scientific review article
Glossary of common terms
Next Steps! Clinical trials groups in COLONTOWN
Tools You Can Use
Which tests might be useful for me? A cheat sheet
My CRC biomarkers worksheet
Liquid Biopsy/ctDNA Testing: Signatera
What is Signatera?
What will I learn?
How do I get tested?
How can I get costs reimbursed?
What do my results mean?
Details to give your doctor
Signatera conversations in COLONTOWN
Current CRC studies using Signatera
Signatera video resources
Who is ordering Signatera? A partial provider list
Signatera research update
Liquid Biopsy/ctDNA (for MRD) Testing: Guardant Reveal
What is Guardant Reveal?
What will I learn?
How do I get tested?
How can I get costs reimbursed?
What do my results mean?
Details to give your doctor
Liquid biopsy conversations in COLONTOWN
Liquid Biopsy/ctDNA Testing: Guardant360®
What is Guardant360® CDx?
What will I learn?
How do I get tested?
How can I get costs reimbursed?
What do my results mean?
Details to give your doctor
Liquid biopsy conversations in COLONTOWN
Tumor mutational burden (TMB): Blood/plasma vs tissue
Tissue Testing: Immunoscore®
What is Immunoscore®?
What will I learn?
How do I get tested?
How can I get costs reimbursed?
What do my results mean?
Details to give your doctor
Personalized biomarker worksheet
Additional Immunoscore® resources
Questions? Feedback?
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Which tests might be useful for me? A cheat sheet

Diagnostic and Surveillance Testing Which tests might be useful for me? A cheat sheet

If you are a stage I patient

  • At diagnosis
  • And have had surgery
    • Signatera (if treatment-naive tissue is available)
  • And have an enlarged lymph node or suspected spot on an organ
    • Signatera, if treatment-naive tissue is available

If you are a stage II patient

If you are a stage III patient

If you are a stage IV patient

  • At diagnosis 
  • On targeted therapy (herceptin, vectibix, erbitux, BRAF inhibitor, MEKi, immunotherapy):
  • Looking for tumor genotyping or mutational information
  • On chemotherapy
  • At progression

If you are in NED/Surveillance Mode

If you are not in treatment, but see an increase in CEA

  • Signatera, if treatment-naive tissue is available
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