CIRCULATE-US: Who is eligible to join?
Patients are eligible to join if they:
- Are 18 years and older and have been diagnosed with stage II or III adenocarcinoma of the colon
- Had surgery to completely remove the primary tumor between 7 and 60 days ago
- Have a microsatellite stable (MSS) tumor
- Previously tested positive for ctDNA with a Signatera assay
- Have an ECOG performance status of 0 or 1
- Have blood, liver and kidney function tests within certain limits
Patients are ineligible to join this trial if they:
- Have previously been treated with chemotherapy, targeted therapy, immunotherapy, or radiation therapy
- Have a microsatellite unstable (MSI-H) tumor
- Are not a candidate for systemic chemotherapy (such as FOLFOX, CAPOX and FOLFOXIRI)
- Are pregnant, breastfeeding, or plan to become pregnant during the study
- Have a history of any colon cancer other than adenocarcinoma
- Have both primary rectal and colon cancers
- Have a history of any kind of metastases
There are additional eligibility requirements for this study: see the complete list at clinicaltrials.gov. Contact your doctor if you are unsure of your eligibility. You can also contact a study doctor who will review the criteria with you and help determine your eligibility.
Note: High risk stage II & III colon cancer patients who got a positive Signatera test outside the trial are also eligible to enroll in the trial.