A test done on a tumor sample to assess biological makeup, such as mutations or biomarkers.
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Category: Glossary
Colorectal cancer that arises from the left and right sides of the large intestine have differences in their molecular makeup — which makes them more or less responsive to certain drug combinations.
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Wash-out period
A period of time that a trial participant must be off treatment before starting a particular trial.
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Time to treatment failure (TTF)
The amount of time on a particular treatment before a patient’s tumor grows or spreads.
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Time to treatment discontinuation (TTD)
The amount of time from when the treatment started to when it stopped.
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Trial coordinator
The person in charge of supervising the trial, recruiting patients and screening them for eligibility. Trial coordinators will often be site-specific.
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Stratification
Dividing up subjects for analysis based on something other than the drug or treatment. This could be factors like age, gender, or other demographic information.
One who funds and oversees the trial. They are also responsible for collecting and analyzing the data. This could be an individual, company, academic institution or organization.
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Safety lead-in
When a small group of patients are given a particular drug or treatment before it’s given to the majority of patients enrolled in the trial. This is to test for safety and ensure that the drug does not provoke too many adverse events. Not all trials have safety lead-ins.
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Refractory
A tumor that fails to respond to medical treatment.